Author

M. Laine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

D. J. Hosfield· 2 shared G. L. Greene· 2 shared S. W. Fanning· 2 shared C. E. Fowler· 1 shared C. G. Mayne· 1 shared E. Nduwke· 1 shared E. Sullivan· 1 shared E. Tajkhorshid· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersCancer Biology

D. J. Hosfield

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2 papers

Recent·Most cited

Stereo-specific Lasofoxifene Derivatives Reveal the Interplay between Estrogen Receptor Alpha Stability and Antagonistic Activity in ESR1 Mutant Breast Cancer Cells

D. J. Hosfield, S. Weber, N.-S. Li, M. Suavage, E. Sullivan, E. Nduwke, R. Han, S. Cush, M. Laine, S. C. Mader, G. L. Greene, S. W. Fanning

The paper synthesizes lasofoxifene derivatives to study how ER cellular lifetime and antagonistic activity relate in ESR1 mutant breast cancer cells, finding that reducing ER lifetime does not always enhance transcriptional antagonism.

bioRxiv · Aug 27, 2021Cancer Biology

The SERM/SERD Bazedoxifene Disrupts ESR1 Helix 12 to Overcome Acquired Hormone Resistance in Breast Cancer Cells

S. W. Fanning, R. Jeselsohn, V. Dharmarajan, C. G. Mayne, M. Karimi, G. Buchwalter, R. Houtman, W. Toy, C. E. Fowler, M. Laine, K. E. Carlson, T. A. Martin, J. Nowak, J. C. Nwachukwu, D. J. Hosfield, , G. L. Greene

This study shows that bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells by inhibiting Y537S and D538G ER mutants more effectively than tamoxifen.

bioRxiv · Apr 23, 2018Cancer Biology