Author

J. Nowak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Assay:clinical cohort / trial· 1 Research Focus:clustering· 1

Frequent Co-Authors

A. Albrecht· 2 shared D. Pfennig· 2 shared P. J. Walla· 2 shared A. Bujotzek· 1 shared A. Dowdye· 1 shared A. K. Tewari· 1 shared A. L. Damon· 1 shared A. P. Lewis· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersBiophysics

A. Albrecht

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A patient-driven clinicogenomic partnership through the Metastatic Prostate Cancer Project

J. Crowdis, S. Balch, L. Sterlin, B. S. Thomas, S. Y. Camp, M. Dunphy, E. Anastasio, S. Shah, A. L. Damon, R. Ramos, D. M. Sosa, I. K. Small, B. Tomson, C. M. Nguyen, M. McGillicuddy, , E. M. Van Allen

The paper describes a patient-driven initiative that collects clinicogenomic data from metastatic prostate cancer patients, revealing consistent patient-reported data and genomic insights from cfDNA samples.

bioRxiv · Jul 9, 2021 · PreprintCancer Biology

A device for exploring the full angular excitation space - Can more angular projections improve determination of a molecules 3D-orientation in the presence of noise?

D. Pfennig, A. Albrecht, J. Nowak, P. J. Walla

This study investigates whether more angular projections improve 3D orientation determination of single molecules in noisy conditions and finds that three projections provide maximum information.

bioRxiv · Mar 11, 2020Biophysics

Amplitude Analysis of Polarization Modulation Data and 3D-Polarization Demodulation (3D-SPoD)

A. Albrecht, D. Pfennig, J. Nowak, R. Matis, M. Schaks, N. Hafi, K. Rottner, P. J. Walla

This paper analyzes the amplitude of polarization modulation data in 3D-SPoD to improve structure reconstruction and reduce background noise in super-resolution imaging.

bioRxiv · Mar 10, 2020 · PreprintBiophysics

The Therapeutic Antibody Profiler (TAP): Five Computational Developability Guidelines

M. Raybould, C. Marks, K. Krawczyk, B. Taddese, J. Nowak, A. P. Lewis, A. Bujotzek, J. Shi, C. M. Deane

The paper introduces TAP, a tool that identifies developability issues in therapeutic antibodies using five computational guidelines based on structural and charge properties.

bioRxiv · Jun 29, 2018Immunology

The SERM/SERD Bazedoxifene Disrupts ESR1 Helix 12 to Overcome Acquired Hormone Resistance in Breast Cancer Cells

S. W. Fanning, R. Jeselsohn, V. Dharmarajan, C. G. Mayne, M. Karimi, G. Buchwalter, R. Houtman, W. Toy, C. E. Fowler, M. Laine, K. E. Carlson, T. A. Martin, J. Nowak, J. C. Nwachukwu, D. J. Hosfield, , G. L. Greene

This study shows that bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells by inhibiting Y537S and D538G ER mutants more effectively than tamoxifen.

bioRxiv · Apr 23, 2018Cancer Biology