Author

M. Leander

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Organism:bacteria (other)· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Q. Cui· 2 shared S. Raman· 2 shared A. Meger· 1 shared Y. Yuan· 1 shared Z. Liu· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 8 mutual co-author links

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2 shared papersBiochemistry

Q. Cui

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2 papers

Recent·Most cited

Deep mutational scanning and machine learning reveal structural and molecular rules governing allosteric hotspots in homologous proteins

M. Leander, Z. Liu, Q. Cui, S. Raman

The paper identifies allosteric hotspots in bacterial transcription factors using deep mutational scanning and machine learning, finding that structural and dynamic properties are key predictors.

bioRxiv · May 1, 2022Biochemistry

Functional Plasticity and Evolutionary Adaptation of Allosteric Regulation

M. Leander, Y. Yuan, A. Meger, Q. Cui, S. Raman

This study uses deep mutational scanning to show that allosteric signaling has high functional plasticity and redundancy, with structural residues more conserved than functional ones.

bioRxiv · Feb 10, 2020Biochemistry