Z. Liu

PanCanSurvPlot: A Large-scale Pan-cancer Survival Analysis Web Application

PanCanSurvPlot provides a web tool for large-scale pan-cancer survival analysis with 215 datasets, 45,000 samples, and customizable survival plots.

Spatiotemporal Single-Cell Roadmap of Human Skin Wound Healing

This study maps the spatiotemporal cellular dynamics of human skin wound healing using single-cell and spatial transcriptomics, identifying FOSL1 as critical for re-epithelialization and highlighting differences in chronic wounds.

A MSTNDel273C mutation with FGF5 knockout sheep by CRISPR/Cas9 promotes skeletal muscle myofiber hyperplasia

This paper describes the creation of MSTNDel273C mutation with FGF5 knockout sheep using CRISPR/Cas9, resulting in skeletal muscle myofiber hyperplasia and a 'double-muscle' phenotype.

Bona fide cytotoxic iNKT cells with superior antitumour responses identified in mice and humans

This study identifies specific iNKT cell subsets in mice and humans with enhanced antitumor activity, suggesting potential improvements for adoptive cell therapies.

SlNAP2 promoted fruit ripening by directly binding the ACS2 promoter and interacting with EIL3

This study identifies SlNAP2 as a NAC transcription factor that promotes tomato fruit ripening by directly binding the ACS2 promoter and interacting with EIL3 to enhance ethylene signaling.

Spatial organization of PI3K-PI(3,4,5)P3-AKT signaling by focal adhesions

This study identifies focal adhesions as the subcellular hubs organizing PI3K-PI(3,4,5)P3-AKT signaling, showing localized lipid production and AKT activation, and demonstrates that combined inhibition of PI3K and FAK enhances cancer cell suppression.

Evaluation of the efficacy of the protopine total alkaloids of Macleaya cordata (Willd.) R. Br. in controlling E. coli infection in broiler chickens

This study evaluates the effectiveness of MPTA extract in reducing E. coli mortality and promoting recovery in infected chickens, finding that 400-1600 mg/kg MPTA-P over 7 days is most effective.

Molecular Insights into AGS3's Role in Spindle Orientation: A Biochemical Perspective

This study investigates AGS3's role in spindle orientation, showing it differs from LGN due to structural differences and regulatory interactions with Insc.

Decoding the anti-aging effect of retinol in reshaping the human skin microbiome niches

This study investigates how retinol affects the human skin microbiome and its role in retinol's anti-aging effects using phenomics, metagenomics, and metabolomics.

scCancerExplorer: a comprehensive database for interactively exploring single-cell multi-omics data of human pan-cancer

scCancerExplorer provides an interactive database for exploring single-cell multi-omics data across 50 cancer types, integrating genomic, epigenomic, and transcriptomic data.

PIN2-mediated self-organizing transient auxin flow contributes to auxin maxima at the tip of Arabidopsis cotyledons

The paper shows that PIN2-mediated transient auxin flow creates auxin maxima at Arabidopsis cotyledon tips, coordinating pavement cell interdigitation.

Hierarchical global and local auxin signals coordinate cellular interdigitation in Arabidopsis

The paper shows auxin signaling coordinates cell shape in Arabidopsis through global and local pathways involving TIR1/AFB and TMK.

Structural basis for membrane remodelling by the AP5:SPG11-SPG15 complex

This study determines the structure of the AP5:SPG11-SPG15 complex and shows it binds PI3P, senses membrane curvature, and drives membrane remodeling in vitro.

Multi-step engineered adeno-associated virus enables whole-brain mRNA delivery

This paper develops a system to package mRNAs into AAVs, enabling efficient whole-brain mRNA delivery in mice.

The genomic and epigenomic dynamics of hemizygous genes across crops with contrasting mating systems

This study examines hemizygous genes in 22 crop genomes, finding higher hemizygosity in clonal lineages and distinct expression and epigenetic features compared to diploid genes.

Engineering the Mechanical Stability of a Therapeutic Affibody/PD-L1 Complex by Anchor Point Selection

The paper investigates how anchor point selection affects the mechanical stability of an Affibody/PD-L1 complex using multiple experimental and computational methods.

Genome sequencing of 'Fuji' apple clonal varieties reveals evolutionary history and genetic mechanism of the spur-type morphology

The paper sequenced clonal Fuji apple varieties to uncover somatic variants linked to spur-type morphology and early maturation traits.

Recognition of RNA secondary structures with a programmable peptide nucleic acid-based platform

This paper introduces daPNAs, a programmable platform combining dbPNAs and asPNAs to target RNA junctions, demonstrating their use in inhibiting Dicer and regulating ribosomal frameshifting.

Coxsackievirus group B3 regulates ASS1-mediated metabolic reprogramming and promotes macrophage inflammatory polarization in viral myocarditis

This study shows CVB3 infection upregulates ASS1 through citrulline consumption, leading to metabolic reprogramming and macrophage inflammatory polarization, contributing to viral myocarditis.

Propiconazole and Tianfengsu Regulated the Growth, Flavor, and Nutrition of Brassica rapa by Brassinosteroid Pathway

This study examines how Propiconazole and Tianfengsu affect Brassica rapa growth, flavor, and nutrition through the brassinosteroid pathway, showing synergistic benefits when used together.

Protein S-glutathionylation confers cell resistance to ferroptosis

This study shows that protein S-glutathionylation protects cells from ferroptosis by maintaining ARF6 function and reducing labile iron pools.

Multi-omics delineate growth factor network underlying exercise effects in an Alzheimer's mouse model

The paper investigates how exercise affects Alzheimer's disease in mice by analyzing gene expression and chromatin changes, finding that growth factor signaling pathways are key to exercise's benefits.

Microbial community assembly during aging of food waste-derived hydrochar: key bacterial guilds mediate nutrient dynamics

This study investigates how adding straw and microbes accelerates hydrochar aging by identifying key bacterial guilds involved in nutrient cycling.

CCR7+ Dendritic Cells Define a Type 17 Module in Psoriasis

The paper identifies CCR7+ dendritic cells as the primary source of IL-23 in psoriasis, linking them to type 17 inflammation and relapse.

Massively parallel interrogation of human functional variants modulating cancer immunosurveillance

The paper identifies functional mutations affecting PD-L1 and HLA-I expression using a large-scale CRISPR screen, revealing clinically relevant variants that influence immunotherapy response.

A rat model of cirrhosis with well-differentiated hepatocellular carcinoma induced by thioacetamide

This study develops a rat model of cirrhosis-induced hepatocellular carcinoma using thioacetamide, showing fibrosis, altered liver architecture, and increased AFP levels.

Unlocking TAS2R14 activation through intricate multi-ligand binding networks

The paper presents cryo-EM structures of TAS2R14 with ligands and G proteins, revealing multi-ligand binding sites and activation mechanisms.

Adaptive Functions of Structural Variants in Human Brain Development

This study identifies human-specific structural variants in rhesus macaques, showing their impact on human brain development through gene expression changes.

Inference of chromosome selection parameters and missegregation rate in cancer from DNA-sequencing data

This paper introduces an algorithm to infer chromosome selection parameters and missegregation rates in cancer using DNA-sequencing data, showing it works well with small datasets.

Engineering probiotic Escherichia coli Nissle 1917 to block transfer of multiple antibiotic resistance genes by exploiting a type I CRISPR-Cas system

This paper engineers Escherichia coli Nissle 1917 to block antibiotic resistance gene transfer using a type I CRISPR-Cas system, showing efficacy in vitro and in zebrafish.