Author

M. Leist

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

C. Karreman· 3 shared A.-K. Holzer· 2 shared I. Suciu· 2 shared C. McGinnis· 1 shared D. Loser· 1 shared E. Kueng· 1 shared E. P. Gonzalez· 1 shared H. Wohlfarth· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersPharmacology & Toxicology

C. Karreman

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4 papers

Recent·Most cited

Generation of human nociceptor-enriched sensory neurons for the study of pain-related dysfunctions

A.-K. Holzer, C. Karreman, I. Suciu, L.-S. Furmanowsky, H. Wohlfarth, D. Loser, W. G. Dirks, E. P. Gonzalez, M. Leist

This paper generates human nociceptor-enriched sensory neurons using iPSCs and evaluates their utility for studying pain-related dysfunctions and drug effects.

bioRxiv · Feb 19, 2022Pharmacology & Toxicology

Specific attenuation of purinergic signaling during bortezomib-induced peripheral neuropathy

A.-K. Holzer, I. Suciu, C. Karreman, T. Goj, M. Leist

This study evaluates the effects of bortezomib on purinergic signaling in matured peripheral neurons, finding specific attenuation of P2X3 signaling at low concentrations.

bioRxiv · Feb 17, 2022 · PreprintPharmacology & Toxicology

Profiling of human neural crest chemoattractant activity as replacement of fetal bovine serum for in vitro chemotaxis assays

X. Dolde, C. Karreman, M. Wiechers, S. Schildknecht, M. Leist

This paper identifies a human-derived chemoattractant for neural crest cells as a potential replacement for fetal bovine serum in chemotaxis assays.

bioRxiv · Jul 19, 2021Pharmacology & Toxicology

Optimization of the TeraTox assay for preclinical teratogenicity assessment

M. Jaklin, J. D. Zhang, N. Schaefer, N. Clemann, P. Barrow, E. Kueng, L. Sach-Peltason, C. McGinnis, M. Leist, S. Kustermann

The paper optimizes the TeraTox assay for teratogenicity prediction using human stem cells and machine learning, achieving 69% accuracy and better sensitivity than existing methods.

bioRxiv · Jul 6, 2021Pharmacology & Toxicology