M. Jaklin

In vitro teratogenicity testing using a 3D, embryo-like gastruloid system

This study uses a 3D gastruloid model to assess teratogenicity of seven reference compounds in mouse and human systems, showing morphological and gene expression changes indicative of developmental defects.

Optimization of the TeraTox assay for preclinical teratogenicity assessment

The paper optimizes the TeraTox assay for teratogenicity prediction using human stem cells and machine learning, achieving 69% accuracy and better sensitivity than existing methods.