Structure dynamics of ApoA-I amyloidogenic variants in small HDL increase their ability to mediate cholesterol efflux
J. O. Lagerstedt, O. Nilsson, M. Lindvall, L. Obici, S. Ekström, R. Del Giudice
The paper shows that ApoA-I amyloidogenic variants form smaller HDL particles with enhanced cholesterol efflux capacity, explaining reduced cardiovascular risk despite lower HDL-cholesterol levels.
bioRxiv · Apr 8, 2020Biochemistry