BiochemistrybioRxiv
Structure dynamics of ApoA-I amyloidogenic variants in small HDL increase their ability to mediate cholesterol efflux
J. O. Lagerstedt, O. Nilsson, M. Lindvall…·R. Del Giudice
The paper shows that ApoA-I amyloidogenic variants form smaller HDL particles with enhanced cholesterol efflux capacity, explaining reduced cardiovascular risk despite lower HDL-cholesterol levels.
DOI 10.1194/jlr.ra120000920