Biological misinterpretation of transcriptional signatures in tumour samples can unknowingly undermine mechanistic understanding and faithful alignment with preclinical data
N. C. Fisher, R. Byrne, H. Leslie, C. Wood, A. Legrini, A. Cameron, B. Ahmaderaghi, S. Corry, S. Malla, R. Amirkhah, A. McCooey, E. Rogan, K. Redmond, S. Sakhnevych, E. Domingo, , P. D. Dunne
The paper shows that transcriptional signatures in tumour samples can be misinterpreted due to stromal influences, affecting alignment with preclinical data.
bioRxiv · Apr 15, 2022 · PreprintCancer Biology