E. Domingo

Innate immune receptor C5aR1 regulates cancer cell fate and can be targeted to improve radiotherapy in tumours with immunosuppressive microenvironments

This study identifies C5aR1 as a targetable receptor on cancer cells that enhances radiotherapy efficacy in immunosuppressive tumours by promoting apoptosis without affecting normal tissues.

Biological misinterpretation of transcriptional signatures in tumour samples can unknowingly undermine mechanistic understanding and faithful alignment with preclinical data

The paper shows that transcriptional signatures in tumour samples can be misinterpreted due to stromal influences, affecting alignment with preclinical data.

Guanosine inhibits hepatitis C virus replication and increases indel frequencies, associated with altered intracellular nucleotide pools

This study shows that guanosine inhibits HCV replication by altering intracellular nucleotide pools, leading to increased indels and reduced viral infectivity.

SARS-CoV-2 Point Mutation and Deletion Spectra, and Their Association with Different Disease Outcome

The paper analyzes SARS-CoV-2 mutant spectra from diagnostic samples and finds higher point mutation complexity in isolates from patients with mild disease compared to moderate or severe disease.

Chromosomal instability mediates immune exclusion and response to cytotoxic chemotherapy in colorectal liver metastases

This study shows that chromosomal instability (CIN) in colorectal liver metastases leads to immune exclusion and poor prognosis but increases sensitivity to DNA-damaging therapies.

A two-level, dynamic fitness landscape of hepatitis C virus revealed by self-organized haplotype maps

This study constructs a dynamic two-layer fitness landscape of HCV using self-organized haplotype maps from deep sequencing data during adaptation in cell culture.

Amino acid substitutions associated with treatment failure of hepatitis C virus infection

The paper identifies six amino acid substitutions associated with HCV treatment failure that are not resistance-associated substitutions but are highly represented in viral quasispecies.

Dissimilar conservation pattern in hepatitis C virus mutant spectra, consensus sequences, and data banks

The paper examines conservation patterns in HCV mutant spectra, consensus sequences, and data banks, finding mismatches that challenge assumptions about sequence conservation for vaccine design.

Negative selection may cause grossly altered but broadly stable karyotypes in metastatic colorectal cancer

This study analyzes longitudinal genomic data from colorectal cancer patients to show that negative selection stabilizes karyotypes during tumor progression and metastasis.

Germline and somatic genetic variants in the p53 pathway interact to affect cancer risk, progression and drug response

The paper investigates interactions between germline and somatic variants in the p53 pathway to show their combined effects on cancer risk, progression, and treatment response.

Image-based consensus molecular subtype classification (imCMS) of colorectal cancer using deep learning

This paper develops imCMS, a deep learning method to classify colorectal cancer subtypes from histological images, showing improved accuracy over bioinformatic methods.

Lethal mutagenesis of Rift Valley fever virus induced by favipiravir

This study shows favipiravir reduces Rift Valley fever virus infectivity in cell cultures and animal models by inducing lethal mutagenesis.