P. D. Dunne

This study identifies impaired vascular function in diabetic iPSCs-derived blood vessel organoids, highlighting a subpopulation of endothelial cells with increased ROS and oxidative phosphorylation.

The paper examines stem cell population dynamics in colorectal tumors, showing that CBC-RSC admixture correlates with mutations and microenvironmental changes, and is linked to chemoresistance.

This study shows that β-catenin signaling in colon cancer cells reduces BTNL expression, impairing γδ T cell immunosurveillance and promoting tumor progression.

The paper shows that transcriptional signatures in tumour samples can be misinterpreted due to stromal influences, affecting alignment with preclinical data.

This study shows that sialylation of stromal cells in tumors enhances immunosuppression and that targeting this process can reverse immune cell exhaustion.

This study develops a semi-automated method for tumor budding assessment in colorectal cancer and compares it with manual methods, finding strong correlation and higher detection rates with the new approach.

This study shows tolinapant, an IAP inhibitor, enhances chemotherapy-induced apoptosis in colorectal cancer by modulating FLIP and HDACs, suggesting its clinical use in poor prognosis MSS CRC with elevated cIAP1/2.

This study identifies FLIP(L) as a p53 target that determines cell fate by promoting cell cycle arrest and inhibiting apoptosis.

The paper identifies Bcl-xL as a prognostic biomarker and predictor of response to adjuvant chemotherapy in BRAF-mutant stage II/III colon cancer using gene expression and immunohistochemistry validation.