Restructuring of the Immune Contexture Improves Checkpoint Blockade Efficacy in Murine Lung Cancer
N. D. Ebelt, E. Zuniga, M. Marzagalli, V. Zamloot, B. R. Blazar, R. Salgia, E. R. Manuel
This study shows that altering the tumor immune landscape with shIDO-ST improves checkpoint blockade efficacy in murine lung cancer by enhancing antigen presentation and reducing suppressive immune cells.
bioRxiv · Oct 9, 2020 · PreprintCancer Biology