PSMA-bearing extracellular vesicles secreted from prostate cancer convert the microenvironment to a tumor-supporting, pro-angiogenic state.
C. M. Machado, M. Skubal, K. Haedicke, F. S. Pittela, E. P. Stater, B. M. Larney, T. L. A. O. Silva, E. T. Costa, C. Masotti, A. H. Otake, L. N. S. Andrade, M. S. Junqueira, H.-T. Hsu, S. Das, E. C. Pratt, , J. Grimm
The paper shows that PSMA-bearing extracellular vesicles from prostate cancer cells promote a pro-angiogenic tumor microenvironment by increasing VEGF-A, angiogenin, and 4EBP-1 phosphorylation.
bioRxiv · Feb 25, 2022 · PreprintCancer Biology