S. Das

Androgen receptor plays critical role in regulating cervical cancer cell migration

This study identifies the androgen receptor as a key regulator in cervical cancer cell migration through network biology and experimental validation.

In-silico studies on structural and thermodynamics basis of interaction of lac repressor protein binding to different DNA operators

This study investigates how the lac repressor protein interacts with two different DNA operators through structural and dynamic changes using molecular modeling and simulations.

In-silico studies on thermodynamics of ligand binding to Fluoride riboswitch aptamer

This paper investigates the conformational stability of the Fluoride riboswitch aptamer in holo and apo forms using molecular dynamics and docking, identifying regions involved in ligand binding and potential non-cognate ligand interactions.

Janus Mazebots and Cellbots Navigating Obstacles in Dense Mammalian Environment

This paper develops Mazebots and cellbots for navigating dense mammalian environments, demonstrating their biocompatibility and potential for biomedical applications.

Molecular Signatures for Microbe-Associated Colorectal Cancers

The paper identifies a Microbe-Associated Colorectal Cancer Signature (MACS) induced by Fusobacterium nucleatum in genetically predisposed hosts, linking microbial infection to early CRC initiation.

Overexpression of α-SNAPRhg1 can improve rhg1-a mediated soybean resistance to soybean cyst nematode

This study shows that overexpressing α-SNAPRhg1 enhances rhg1-a mediated resistance to soybean cyst nematode in transgenic soybean lines, but not against highly virulent SCN populations.

Novel phylogenomic inference and 'Out of Asia' biogeography of cobras, coral snakes, and their allies

The paper infers the evolutionary relationships and biogeography of cobras and coral snakes, rejecting an 'Out of Africa' hypothesis and supporting an 'Out of Asia' scenario.

Unequal genetic redundancies among MYC bHLH transcription factors underlie seedling photomorphogenesis in Arabidopsis

This study identifies the differential roles of MYC3 and MYC4 in seedling photomorphogenesis and their interaction with HY5 and COP1 in Arabidopsis.

Proteome profiling identifies a link between the mitochondrial pathways and host-microbial sensor ELMO1 following Salmonella infection.

This study identifies a link between ELMO1 and mitochondrial pathways in macrophages during Salmonella infection through proteome profiling and functional analysis.

Insulin signaling accelerates the anterograde movement of Rab4 vesicles in axons through Klp98A/KIF16B recruitment via Vps34-PI3Kinase

This study shows insulin signaling increases Rab4 vesicle transport in axons by recruiting Klp98A via Vps34-PI3Kinase activation in Drosophila.

PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2

RMC-113 inhibits PIP4K2C and PIKfyve, reversing SARS-CoV-2-induced autophagic flux impairment and showing antiviral effects.

Ether lipids influence cancer cell fate by modulating iron uptake

This study shows that ether lipids in cancer cells regulate membrane properties to influence iron uptake, ferroptosis, and metastasis, offering a therapeutic target.

Prior exposure to malaria decreases SARS-CoV-2 mediated mortality in K18-hACE2 mice without influencing viral load in lungs

This study shows that prior malaria exposure in K18-hACE2 mice reduces SARS-CoV-2 mortality without affecting lung viral load.

Discovery of free glycated amines and glycated urea as potential markers of diabetic nephropathy

The paper identifies glycated amines and glycated urea in diabetic patients' plasma as potential biomarkers for diabetic nephropathy.

The integrated stress response/eIF2α pathway controls cytokine production in tissue-resident memory CD4+ T cells

This study shows that the ISR/eIF2α pathway regulates cytokine mRNA translation in Trm cells, limiting their activity in homeostasis but enabling rapid response during inflammation or autoimmunity.

Comparative genomic analysis reveals novel phylogenetically intermediate Streptococci with high phenotypic diversity in the human distal lung microbiota.

The paper identifies five new Streptococcus species and one subspecies from human distal lung microbiota, revealing genetic diversity and metabolic functions.

Mitochondria-derived nuclear ATP surge protects against confinement-induced proliferation defects

This study shows that mechanical confinement causes mitochondria to relocate to the nucleus, leading to a nuclear ATP surge that supports DNA repair and cell cycle progression.

Adaptation to ARF6-depletion in KRAS-driven PDAC is abolished by targeting TLR2

This study identifies TLR2 as a target to counteract adaptation to ARF6 depletion in KRAS-driven PDAC, reducing proliferation, migration, and invasion.

Comprehensive Codon Usage Analysis Across Diverse Plant Lineages

This study analyzes codon usage patterns across plant lineages, finding that vascularization influences codon usage more than seed production and identifying dinucleotide biases across species.

Establishment of an intragastric surgical model using C57BL/6 mice to study the vaccine efficacy of OMV-based immunogens against Helicobacter pylori

The paper establishes a surgical model in C57BL/6 mice to study OMV-based vaccine efficacy against H. pylori, showing protective immunity after immunization.

Potential use of Sodium Butyrate (SB) as an anti-virulence agent against Vibrio cholerae targeting ToxT virulence protein.

This paper shows sodium butyrate suppresses virulence in Vibrio cholerae by inhibiting ToxT-DNA binding and reducing toxin production, suggesting it as an anti-virulence agent.

Targeted lipid A modification of Shigella vaccine strains reduced endotoxicity without compromising immunogenicity or invasiveness

This study modifies Shigella lipid A to reduce endotoxicity while maintaining immunogenicity and invasiveness.

Pneumonic plague protection induced by a monophosphoryl lipid A decorated Yersinia outer-membrane-vesicle vaccine

This study develops a pneumonic plague vaccine using OMV46-LcrV, which shows reduced reactogenicity and complete protection in mice against Y. pestis challenge.

Prevotella copri-related effects of a therapeutic food for malnutrition

The paper investigates the role of Prevotella copri in mediating the metabolic effects of a therapeutic food for malnutrition using gnotobiotic mouse models and multi-omics analyses.

Lactobacillus rhamnosus (LR) ameliorates acute respiratory distress syndrome (ARDS) via modulating the lung Innate Lymphoid Cells (ILCs)-Mononuclear Phagocytic System (MPS)

This study shows that Lactobacillus rhamnosus reduces lung inflammation and fibrosis in ALI/ARDS mice by modulating ILCs and MPS.

The role of greater competitive ability in countering age disadvantages in larval competition in Drosophila melanogaster

This study shows that Drosophila melanogaster populations adapted to larval crowding better counter age disadvantages in competition than low-density controls, but differences in egg size and hatching time among these populations do not improve their performance against age-disadvantaged competitors.

Differential expression of miRNAs between Young-Onset and Late-Onset Indian colorectal carcinoma patients

The paper identifies differentially expressed miRNAs between young-onset and late-onset colorectal carcinoma patients and links them to epithelial-mesenchymal transition and tumor progression.

Intercalation of the disulfide bond between the A2 and A4 loop of Cellobiohydrolase (Cel7A) of Aspergillus fumigatus enhances catalytic activity and thermostability

This paper introduces disulfide bonds in the A2 and A4 loop of AfCel7A, enhancing its thermostability and catalytic activity compared to the wild type.

Single Chain Fragment Variable (scFv) corresponding to a novel epitope within HCV envelope protein restricts virus entry into hepatocytes

This study generates a single chain fragment variable (scFv) that targets a novel HCV epitope and inhibits virus entry and replication in vitro and in vivo.

Genital microbiota in infertile couples

This study examines the genital microbiota of infertile couples to assess its association with fertility treatment outcomes.