The evolution of hematopoietic cells under cancer therapy
O. Pich, A. Cortes-Bullich, F. Muinos, M. Pratcorona, A. Gonzalez-Perez, N. Lopez-Bigas
This study investigates how chemotherapy influences the mutation burden and clonal expansion in hematopoietic cells, finding that platinum-based drugs leave a mutational footprint while 5-FU does not.
bioRxiv · Oct 29, 2020Cancer Biology