Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
7 papers
Recent·Most cited
M. Riba, C. Sala, A. Culhane, A. Flobak, A. Patocs, K. Boye, K. Plevova, S. Pospisilova, G. Gandolfi, M. Morelli, G. Bucci, A. Edsjo, U. Lassen, F. Al-Shahrour, N. Lopez-Bigas, , G. Tonon
The paper develops a standardized data model for cancer genomics to enable interoperable data sharing across countries.
bioRxiv · Oct 7, 2023 · PreprintCancer Biology
A. Popa, J.-W. Genger, M. Nicholson, T. Penz, D. Schmid, S. W. Aberle, B. Agerer, A. Lercher, L. Endler, H. Colaco, M. Smyth, M. Schuster, M. Grau, F. Martinez Jimenez, O. Pich, , A. Bergthaler
This study analyzes SARS-CoV-2 superspreading events in Austria using genomic and epidemiological data to understand viral transmission and mutation dynamics.
Science Translational Medicine · Dec 9, 2020Peer-reviewedMicrobiology
O. Pich, A. Cortes-Bullich, F. Muinos, M. Pratcorona, A. Gonzalez-Perez, N. Lopez-Bigas
This study investigates how chemotherapy influences the mutation burden and clonal expansion in hematopoietic cells, finding that platinum-based drugs leave a mutational footprint while 5-FU does not.
bioRxiv · Oct 29, 2020Cancer Biology
F. Muinos, F. Martinez-Jimenez, O. Pich, A. Gonzalez-Perez, N. Lopez-Bigas
This study uses in silico saturation mutagenesis to identify driver mutations in 568 cancer genes across 66 tumor types, revealing how mutation probability and selection influence observed variants.
bioRxiv · Jun 3, 2020Cancer Biology
S. J. Aitken, C. J. Anderson, F. Connor, O. Pich, V. Sundaram, C. Feig, T. F. Rayner, M. Lukk, S. Aitken, J. Luft, E. Kentepozidou, C. Arnedo-Pac, S. Beentjes, S. E. Davies, R. M. Drews, , M. S. Taylor
This study shows that DNA lesions segregate between daughter cells, leading to chromosome-scale mutation phasing and increased genetic diversity in cancer genomes.
bioRxiv · Dec 8, 2019Cancer Biology
L. Alexandrov, J. Kim, N. J. Haradhvala, M. N. Huang, A. W. T. Ng, Y. Wu, A. Boot, K. R. Covington, D. A. Gordenin, E. Bergstrom, S. M. A. Islam, N. Lopez-Bigas, L. J. Klimczak, J. R. McPherson, S. Morganella, , M. R. Stratton
The paper characterizes 49 mutational signatures in human cancer using a large dataset of somatic mutations, revealing associations with exposures and DNA repair mechanisms and identifying signatures of unknown origin.
bioRxiv · Jul 3, 2019Cancer Biology
D. Tamborero, C. Rubio-Perez, J. Deu-Pons, M. P. Schroeder, A. Vivancos, A. Rovira, I. Tusquets, J. Albanell, J. Rodon, J. Tabernero, C. de Torres, R. Dienstmann, A. Gonzalez-Perez, N. Lopez-Bigas
The paper introduces a tool to annotate and interpret the biological and clinical relevance of tumor genomic alterations.
bioRxiv · Jun 21, 2017Cancer Biology