Structure of the human inner kinetochore bound to a centromeric CENP-A nucleosome
S. Yatskevich, K. W. Muir, D. Bellini, Z. Zhang, J. Yang, T. Tischer, M. Predin, T. Dendooven, S. H. McLaughlin, D. Barford
The paper describes the cryo-EM structure of the human inner kinetochore CCAN complex bound to a CENP-A nucleosome, revealing how it grips linker DNA for chromosome segregation.
bioRxiv · Jan 7, 2022Biochemistry