Author

M. Pugh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Approach:experimental assay· 2 Research Focus:spatial domain detection· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

G. S. Taylor· 2 shared A. Angelillo-Scherrer· 1 shared A. Culhane· 1 shared A. Filer· 1 shared A. Gazdhar· 1 shared A. P. Croft· 1 shared A. Tardivel· 1 shared A. Teodosio· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersImmunology

G. S. Taylor

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Author profile →

3 papers

Recent·Most cited

Multi-omic spatial profiling reveals the unique virus-driven immune landscape of COVID-19 placentitis

M. Pugh, E. Fennel, C. I. Leahy, T. Perry, B. Hargitai, T. Marton, K. J. Hunter, G. Halford, H. O. Yilmaz, Z. Stamataki, G. Reynolds, H. J. Hill, B. E. Willcox, N. M. Steven, C. A. Thornton, , G. S. Taylor

The paper uses multi-omic spatial profiling to show that SARS-CoV-2 infection in the placenta leads to a distinct immune signature with PDL1-expressing macrophages and T-cell exclusion.

bioRxiv · Nov 14, 2022 · PreprintImmunology

A cellular and spatial map of salivary glands at single cell resolution reveals the functional basis of tertiary lymphoid structure formation in Sjogren's syndrome

S. Nayar, J. D. Turner, S. Asam, E. Fennell, M. Pugh, S. Colafrancesco, O. Berardicurti, C. G. Smith, J. Flint, A. Teodosio, V. Iannizzotto, D. G. Gardner, J. v. Roon, I. Korsunsky, Roche Fibroblast Network Consortium, , F. Barone

This study maps cellular and spatial features of tertiary lymphoid structures in human salivary glands at single-cell resolution, identifying novel cell states and their roles in TLS formation.

bioRxiv · Nov 3, 2022 · PreprintImmunology

LRR protein RNH1 dampens the inflammasome activation and is associated with adverse clinical outcomes in COVID-19 patients

G. Bombaci, M. A. Sarangdhar, N. Andina, A. Tardivel, E. C.-W. Yu, G. M. Mackie, M. Pugh, V. B. Ozan, Y. Banz, T. Spinetti, C. Hirzel, E. Youd, J. C. Schefold, G. S. Taylor, A. Gazdhar, , R. Allam

This study identifies RNH1 as an inhibitor of inflammasome activation, showing its protective role in limiting inflammation and its association with worse outcomes in COVID-19.

bioRxiv · Apr 12, 2021 · PreprintImmunology