A. Filer

A longitudinal single-cell therapeutic atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease

This study creates a therapeutic atlas of anti-TNF treatment in IBD, showing disease- and therapy-specific cellular changes and identifying IFN signalling as a potential target for JAK inhibition.

Clonal associations of lymphocyte subsets and functional states revealed by single cell antigen receptor profiling of T and B cells in rheumatoid arthritis synovium

This study uses single-cell antigen receptor profiling to identify clonal relationships and functional states of T and B cells in RA synovium.

LAT1 enables T cell activation under inflammatory conditions: a new therapeutic target for rheumatoid arthritis

This study shows LAT1 is critical for T cell activation in rheumatoid arthritis and identifies it as a therapeutic target, with a LAT1 inhibitor effective in mouse models.

A cellular and spatial map of salivary glands at single cell resolution reveals the functional basis of tertiary lymphoid structure formation in Sjogren's syndrome

This study maps cellular and spatial features of tertiary lymphoid structures in human salivary glands at single-cell resolution, identifying novel cell states and their roles in TLS formation.

Loss of α2-6 sialylation promotes the transformation of synovial fibroblasts into a pro-inflammatory phenotype in Rheumatoid Arthritis.

This study shows that reduced α2-6 sialylation in synovial fibroblasts contributes to a pro-inflammatory phenotype in RA by altering glycosylation pathways.

Pathologically distinct fibroblast subsets drive inflammation and tissue damage in arthritis

The paper identifies two distinct fibroblast subsets in arthritis that drive inflammation or tissue damage, showing their unique roles in disease progression.

Defining Inflammatory Cell States in Rheumatoid Arthritis Joint Synovial Tissues by Integrating Single-cell Transcriptomics and Mass Cytometry

The paper identifies key inflammatory cell states in RA synovial tissues using integrated single-cell and mass cytometry data from patient samples.

High dimensional analyses of cells dissociated from cryopreserved synovial tissue

This paper establishes a protocol for dissociating cryopreserved synovial tissue to obtain viable cells with preserved transcriptomes and surface markers, enabling high-dimensional analysis of rheumatoid arthritis pathology.

Single Cell Transcriptomics And Flow Cytometry Reveal Disease-Associated Fibroblast Subsets In Rheumatoid Arthritis

The paper identifies disease-associated fibroblast subsets in rheumatoid arthritis using single-cell transcriptomics and flow cytometry, revealing subset-specific markers and functional differences.