Acquired resistance to anti-PD1 therapy in patients with NSCLC reveals changes in T cell phenotypes and MET amplification
S. Hiltbrunner, L. Cords, S. Kasser, S. N. Freiberger, S. Kreutzer, N. C. Toussaint, L. Grob, I. Opitz, M. Messerli, M. Zoche, A. Soltermann, M. Rechsteiner, M. van den Broek, B. Bodenmiller, A. Curioni-Fontecedro
This study identifies two patterns of acquired resistance to anti-PD1 therapy in NSCLC patients, including reduced T cell infiltration and MET amplification.
bioRxiv · Apr 8, 2022 · PreprintCancer Biology