BiochemistrybioRxiv
Structural analysis of cholesterol binding and sterol selectivity by ABCG5/G8
D. Farhat, F. Rezaei, M. Ristovski…·J.-Y. Lee
This study determines the crystal structure of ABCG5/G8 in a cholesterol-bound state and identifies a conserved phenylalanine array that supports sterol selectivity.
DOI 10.1016/j.jmb.2022.167795