J.-Y. Lee

Transcriptome Profiling and Characterization of Peritoneal Metastasis Ovarian Cancer Xenografts in Humanized Mice

This study establishes a humanized mouse model of ovarian cancer to evaluate immune checkpoint inhibitor efficacy and identifies gene expression patterns associated with resistance.

Genomic hypomethylation in cell-free DNA predicts responses to checkpoint blockade in lung and breast cancer

This study develops iMethyl, a method to estimate genomic hypomethylation from cell-free DNA to predict responses to immune checkpoint blockade in cancer patients.

Pan-cancer analysis reveals multifaceted roles of retrotransposon-fusion RNAs

The paper identifies cancer-specific transposon-fusion RNAs across 34 cancer types and finds they are associated with tumor suppressors and oncogenes, and can activate T-cells.

Endosomal egress and intercellular transmission of hepatic ApoE-containing lipoproteins and its exploitation by the hepatitis C virus

This paper identifies the endosomal egress pathway of hepatic ApoE-containing lipoproteins and shows how the hepatitis C virus exploits this route for intercellular transmission.

Comparative Interactome Analysis of α-arrestin Families in Human and Drosophila

This study constructs and compares interactomes of α-arrestins in human and Drosophila, identifying conserved and species-specific binding partners and revealing TXNIP's role in modulating chromatin structure.

Nutlin-3a induced KRAS mutant lung cancer specific methuosis-like cell death is dependent on GFPT2

The paper shows that nutlin-3a induces methuosis-like cell death in KRAS mutant NSCLC cells dependent on GFPT2.

Stochastic characterization of navigation strategies in an automated variant of the Barnes maze

The paper develops an automated Barnes maze to study navigation strategies in mice, showing a shift from random to spatial and serial strategies over time.

Darapladib, an inhibitor of Lp-PLA2, sensitizes cancer cells to ferroptosis by remodeling lipid metabolism

This study shows that darapladib, an Lp-PLA2 inhibitor, enhances ferroptosis in cancer cells by altering lipid metabolism and synergizes with GPX4 inhibitors to suppress tumor growth.

Evaluation of antiviral drugs against newly emerged SARS-CoV-2 Omicron variants

This study evaluates the antiviral efficacy of remdesivir, molnupiravir, and nirmatrelvir against newly emerged SARS-CoV-2 Omicron subvariants and finds they retain antiviral activity.

Targeting of plasmodesmal proteins requires unconventional signals

The paper identifies novel unconventional targeting signals in PDLP5 and related proteins that mediate plasmodesmal localization and function.

Comparison of HAV and HCV infections in vivo and in vitro reveals distinct patterns of innate immune evasion and activation

This study compares HAV and HCV infections in vivo and in vitro, revealing that HAV induces an innate immune response via MDA5/LGP2 with limited protease-mediated suppression, while HCV activates TLR3 without TRIF cleavage.

Combination therapy with nirmatrelvir and molnupiravir improves the survival of SARS-CoV-2 infected mice

This paper evaluates combination antiviral therapies in SARS-CoV-2 infected mice, finding that nirmatrelvir and molnupiravir together significantly improve survival compared to monotherapies.

Structural analysis of cholesterol binding and sterol selectivity by ABCG5/G8

This study determines the crystal structure of ABCG5/G8 in a cholesterol-bound state and identifies a conserved phenylalanine array that supports sterol selectivity.

Disease diagnostics using machine learning of immune receptors

The paper develops Mal-ID, a machine learning framework using immune receptor data to diagnose diseases, detecting infections, autoimmune disorders, and vaccine responses.

Relative infectivity of the SARS-CoV-2 Omicron variant in human alveolar cells

This study compares the infectivity of SARS-CoV-2 variants in human alveolar cells, finding Omicron (BA.1) to be 3-5-fold more infectious than other variants at early infection.

A Hepatitis C virus genotype 1b post transplant isolate with high replication efficiency in cell culture and its adaptation to infectious virus production in vitro and in vivo

This paper develops an efficient HCV genotype 1b infectious cell culture model through adaptation, enabling vaccine development and understanding viral evolution post-transplant.

A global lipid map reveals host dependency factors conserved across SARS-CoV-2 variants

The paper identifies glycerolipid biosynthesis as a conserved host dependency factor for SARS-CoV-2 by mapping lipid metabolism changes across variants.

Metabolomic, photoprotective, and photosynthetic acclimatory responses to post-flowering drought in sorghum

The paper investigates drought tolerance in sorghum by analyzing metabolomic, physiological, and transcriptomic responses to post-flowering drought in two genotypes.

SARS-CoV-2 Infection of Microglia Elicits Pro-inflammatory Activation and Apoptotic Cell Death

This paper shows SARS-CoV-2 directly infects human microglia, causing pro-inflammatory activation and apoptosis, which may contribute to neurological issues in COVID-19 patients.

The in vitro and in vivo potency of CT-P59 against Delta and its associated variants of SARS-CoV-2

This study evaluates CT-P59's antiviral activity against Delta and its variants, showing reduced in vitro potency but effective in vivo neutralization and symptom remission in mice.

Convergent use of phosphatidic acid for Hepatitis C virus and SARS-CoV-2 replication organelle formation

This study identifies phosphatidic acid as critical for double membrane vesicle formation in HCV and SARS-CoV-2 replication, suggesting host-targeted PA synthesis inhibition as a therapeutic strategy.

RORα enforces stability of the T-helper-17 cell effector program

This study shows ROR is essential for maintaining Th17 cell effector function through cooperative binding with ROR{gamma}t to an enhancer element.

Shared B cell memory to coronaviruses and other pathogens varies in human age groups and tissues

The paper examines age-related differences in B cell memory to coronaviruses and other pathogens across tissues and age groups, finding higher frequencies of class-switched memory B cells in children.

Transmembrane polar relay drives the allosteric regulation for ABCG5/G8 sterol transporter

This study investigates the role of the transmembrane polar relay in ABCG5/G8 sterol transporter function using genetic variants and biochemical assays.

Pyronaridine and artesunate are potential antiviral drugs against COVID-19 and influenza

This study identifies pyronaridine and artesunate as potential antiviral drugs effective against SARS-CoV-2 and influenza viruses in human lung cells.

SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB

This study shows SARS-CoV-2 triggers a pro-inflammatory cytokine response via cGAS-STING and NF-κB in epithelial cells, which may contribute to severe disease.

Molecular mapping of qBK1Z, a major QTL for bakanae disease resistance in rice

This study identifies a major QTL, qBK1Z, for bakanae disease resistance in rice using QTL mapping in recombinant inbred lines derived from a resistant and susceptible variety.

A global lipid map defines a network essential for Zika virus replication

This study identifies a sphingolipid metabolic network critical for Zika virus replication and shows ceramide flux mediates infection.

Serum Amyloid A Proteins Induce Pathogenic TH17 Cells and Promote Inflammatory Disease

This study shows serum amyloid A proteins drive pathogenic TH17 cell differentiation and promote inflammatory disease through STAT3-activating cytokines.