Fam72a controls the balance between error-prone and error-free DNA repair during antibody diversification.
M. Rogier, J. Moritz, I. Robert, C. Lescale, V. Heyer, A.-S. Thomas-Claudepierre, A. Abello, L. Deriano, B. Reina-San-Martin
This study identifies FAM72A as a regulator of UNG2 levels, affecting DNA repair balance and mutation rates during antibody diversification.
bioRxiv · Dec 22, 2020Immunology