From breast cancer cell homing to the onset of early bone metastasis: dynamic bone (re)modeling as a driver of metastasis
S. A. E. Young, A.-D. Heller, D. S. Garske, M. Rummler, V. Qian, A. Ellinghaus, G. N. Duda, B. Willie, A. Grueneboom, A. Cipitria
This study develops a mouse model and multimodal 3D imaging to analyze cancer cell homing and dynamic bone remodeling during early bone metastasis, revealing osteolytic lesions in specific bone regions.
bioRxiv · Jan 24, 2023 · PreprintBioengineering