Antidepressants stimulate lipoprotein(a) macropinocytosis via serotonin-enhanced cell surface binding
N. Deo, H. Siddiqui, G. Madani, M. Rutledge, M. Williams, S. P. McCormick, G. M. I. Redpath
This study shows antidepressants like imipramine and citalopram enhance Lp(a) uptake via serotonin-mediated cell surface binding and PlgRKT receptor upregulation, suggesting potential therapeutic use for lowering Lp(a) in depression patients.
bioRxiv · Mar 26, 2021Cell Biology