Cell BiologybioRxiv
Antidepressants stimulate lipoprotein(a) macropinocytosis via serotonin-enhanced cell surface binding
N. Deo, H. Siddiqui, G. Madani…·G. M. I. Redpath
This study shows antidepressants like imipramine and citalopram enhance Lp(a) uptake via serotonin-mediated cell surface binding and PlgRKT receptor upregulation, suggesting potential therapeutic use for lowering Lp(a) in depression patients.
DOI 10.1016/j.jlr.2025.100889