Intergenerational metabolic priming by sperm piRNAs
Adelheid M. Lempradl, Unn Örtegren Kugelberg, Mary Iconomou, Ian Beddows, Daniel Nätt, Eduard Casas, Lovisa Örkenby, Lennart Enders, Alejandro Gutierrez Martinez, Oleh V. Lushchak, Erica G. M. Boonen, Tamina Rückert, M. Sabev, Marie G.L. Roth, Dean Pettinga, , John Andrew Pospisilik
This study shows that paternal dietary sugar affects offspring gene expression through sperm piRNA pathways, linking small RNA regulation to intergenerational epigenetic inheritance.
bioRxiv · Mar 29, 2021 · PreprintDevelopmental Biology