A series of Orai1 gating checkpoints in transmembrane and cytosolic regions requires clearance for CRAC channel opening
A. Tiffner, R. Schober, C. Hoeglinger, D. Bonhenry, S. Pandey, V. Lunz, m. Sallinger, I. Frischauf, M. Fahrner, S. Lindinger, L. Maltan, S. Berlansky, M. Stadlbauer, R. Schindl, R. Ettrich, , I. Derler
This study identifies Orai1 gating checkpoints that must be cleared for CRAC channel opening, using a library of double mutants and structural analysis.
Journal of Biological Chemistry · Jan 1, 2021Peer-reviewedBiophysics