HIV-1 uncoating by release of viral cDNA from capsid-like structures in the nucleus of infected cells.
T. G. Müller, V. Zila, K. Peters, S. Schifferdecker, M. Stanic, B. Lucic, V. Laketa, M. Lusic, B. Müller, H.-G. Kräusslich
The paper visualizes HIV-1 cDNA in nuclei using CLEM and shows that uncoating occurs via physical disruption of capsid-like structures, not cooperative disassembly.
bioRxiv · Nov 13, 2020Microbiology