V. Laketa

Endosomal egress and intercellular transmission of hepatic ApoE-containing lipoproteins and its exploitation by the hepatitis C virus

This paper identifies the endosomal egress pathway of hepatic ApoE-containing lipoproteins and shows how the hepatitis C virus exploits this route for intercellular transmission.

Phosphatidylinositol 4-kinase III alpha governs cytoskeletal organization for invasiveness of liver cancer cells

This study identifies PI4KIII's role in promoting liver cancer invasiveness through cytoskeletal reorganization via PIK3C2γ and Akt2/paxillin-cofilin signaling.

A Hepatitis C virus genotype 1b post transplant isolate with high replication efficiency in cell culture and its adaptation to infectious virus production in vitro and in vivo

This paper develops an efficient HCV genotype 1b infectious cell culture model through adaptation, enabling vaccine development and understanding viral evolution post-transplant.

ARPC5 Isoforms and Their Regulation by Calcium-Calmodulin-N-WASP Drive Distinct Arp2/3-dependent Actin Remodeling Events in CD4 T Cells

The paper identifies distinct roles of ARPC5 isoforms in regulating Arp2/3-dependent actin remodeling in CD4 T cells under different stimuli.

Direct capsid labeling of infectious HIV-1 by genetic code expansion allows detection of largely complete nuclear capsids and suggests nuclear entry of HIV-1 complexes via common routes

This study uses genetic code expansion to label HIV-1 capsid proteins, enabling visualization of complete nuclear capsids and suggesting common nuclear entry routes.

Asynchronous nuclear cycles in multinucleated Plasmodium falciparum enable rapid proliferation

The paper shows that Plasmodium falciparum nuclei replicate DNA asynchronously, leading to heterogeneous progeny numbers and slower replication during overlapping events.

The FDA-approved drug cobicistat synergizes with remdesivir to inhibit SARS-CoV-2 replication

This study shows that cobicistat synergizes with remdesivir to inhibit SARS-CoV-2 replication in cell lines and organoids, reducing viral replication to levels comparable to uninfected cells.

Microscopy-based assay for semi-quantitative detection of SARS-CoV-2 specific antibodies in human sera

The paper develops a semi-quantitative microscopy-based assay to detect SARS-CoV-2 specific antibodies in human sera, providing a sensitive and specific method for serological analysis.

HIV-1 uncoating by release of viral cDNA from capsid-like structures in the nucleus of infected cells.

The paper visualizes HIV-1 cDNA in nuclei using CLEM and shows that uncoating occurs via physical disruption of capsid-like structures, not cooperative disassembly.

A versatile reporter system to monitor virus infected cells and its application to dengue virus and SARS-CoV-2

This paper introduces a versatile reporter system that detects virus-infected cells by using protease activity and applies it to dengue virus and SARS-CoV-2.

Post-correlation on-lamella cryo-CLEM reveals the membrane architecture of lamellar bodies

The paper uses cryo-CLEM to study lamellar bodies in their unperturbed state, revealing their membrane architecture and a new outer membrane dome protein complex.