An autoregulatory feedback loop converging on H2A ubiquitination drives synovial sarcoma
N. S. Benabdallah, V. Dalal, A. Sotiriou, R. W. Scott, F. K. Kommoss, A. Pejkovska, L. Gaspar, L. Wagner, F. J. Sanchez-Rivera, M. Ta, S. Thornton, T. O. Nielsen, T. M. Underhill, A. Banito
This study identifies an autoregulatory feedback loop involving H2A ubiquitination that enhances SS18-SSX fusion protein chromatin binding and oncogenic activity in synovial sarcoma.
bioRxiv · Jul 18, 2022 · PreprintCancer Biology