A. Sen

Deubiquitinase JOSD1 tempers hepatic proteotoxicity

This study identifies JOSD1 as a deubiquitinase that mitigates hepatic proteotoxicity by stabilizing SOCS1 and enhancing cell survival under proteasome inhibitor stress.

Comprehensive gene expression analysis of organoid-derived healthy human colonic epithelium and cancer cell line by stimulated with live probiotic bacteria

The paper compares gene expression in healthy human colonic organoid cells and cancer cell lines after coculture with probiotic bacteria, identifying distinct gene signatures and functional changes.

Cytoskeletal activation of NHE1 regulates mechanosensitive cell volume adaptation and proliferation

This study identifies a mechanism where cytoskeletal activation of NHE1 drives secondary volume increase and affects cell proliferation in response to hypotonic stress.

A paper based microfluidic platform combining LAMP-CRISPR/Cas12a for fluorometric detection of nucleic acids

This paper demonstrates a paper-based microfluidic platform combining LAMP and CRISPR/Cas12a for specific nucleic acid detection, reducing false positives and improving robustness and cost-effectiveness compared to conventional methods.

Yeast and Mammalian Epsins Use Different Determinants for Localization and Function: Role of Clathrin/AP2/Ubiquitin Binding Motifs and Poly-Glutamine Stretches

This study compares yeast and mammalian Epsin localization and function, identifying differences in binding determinants and highlighting the role of poly-glutamine stretches.

Quantification of salt stress in wheat leaves by Raman spectroscopy and machine learning

This paper uses Raman spectroscopy combined with machine learning to quantify salt stress in wheat leaves and predict stress levels accurately.

Vitronectin acts as a key regulator of adhesion and migration in human umbilical cord-derived MSCs under different stress conditions

This study identifies vitronectin as a key regulator of adhesion and migration in WJ-MSCs under serum starvation stress, but not hypoxia.

Enzyme Catalysis Enhances Lateral Lipid Motility and Directional Particle Transport on Membranes

This study shows enzyme catalysis enhances lateral lipid diffusion and directional particle transport in lipid membranes, demonstrating active control over membrane dynamics.

Enzyme Aggregation and Fragmentation Induced by Catalysis Relevant Species

The paper examines enzyme aggregation and fragmentation during catalysis in three model enzymes, finding that specific substrates and ions induce structural changes without affecting catalytic activity.

Mitochondrial membrane proteins and VPS35 orchestrate selective removal of mtDNA

The paper identifies a mechanism involving Twinkle, ATAD3, SAMM50, and VPS35 that selectively removes mutant mtDNA through autophagy, offering therapeutic potential for mtDNA diseases and aging.

Allele-specific expression links diverse cis-regulatory mutations to recurrent gene dysregulation in high-risk neuroblastoma

The paper uses allele-specific expression analysis in neuroblastoma tumors to identify genes dysregulated by cis-regulatory mutations and copy number alterations.

Leveraging Allele-Specific Expression for Therapeutic Response Gene Discovery in Glioblastoma.

This study identifies genes with allele-specific expression in glioblastoma stem cells, finding SLFN11 loss linked to drug resistance and susceptibility to Zika virus.

Estrogen receptors in human bladder cells regulate innate cytokine responses to differentially modulate uropathogenic E. coli colonization

This study shows estrogen receptors ER and ERβ protect against uropathogenic E. coli colonization in bladder cells by modulating cytokine and receptor gene expression, while GPR30 has the opposite effect.

Ubiquitination and Phosphorylation are Independently Required for Epsin-Mediated Internalization of Cargo in S. cerevisiae

This study shows that ubiquitination and phosphorylation independently regulate epsin-mediated internalization of the yeast Na+ pump Ena1.

A comprehensive and comparative study on the action of pentacyclic triterpenoids on Vibrio cholerae biofilms.

This study evaluates the antibiofilm effects of three pentacyclic triterpenoids on V. cholerae biofilms, revealing their impact on biofilm formation, structure, and interactions with quorum sensing systems.

Rotavirus re-programs multiple IFN receptors and restricts their intestinal antiviral and inflammatory functions

This study shows rotavirus reprograms IFN receptors to suppress antiviral and inflammatory responses in the intestine.

Motility of Enzyme-Powered Vesicles

The paper demonstrates that enzyme-powered vesicles exhibit increased motility with higher enzymatic turnover rates, using optical microscopy to track their movement.

Non-uniform Crowding Enhances Transport: Relevance to Biological Environments

The paper shows that non-uniform crowder distributions enhance tracer transport in biological environments, with implications for intracellular transport mechanisms.

Clueless forms dynamic, insulin-responsive bliss particles sensitive to stress

The paper identifies Clu particles as dynamic, insulin-responsive, stress-sensitive ribonucleoprotein structures in Drosophila that are absent under metabolic stress and affect mitochondrial function.

Functional Balance between TCF21-Slug defines phenotypic plasticity and sub-classes in high-grade serous ovarian cancer

The paper identifies TCF21-Slug interactions that define phenotypic plasticity and sub-classes in high-grade serous ovarian cancer.

Proximity labeling reveals an extensive steady-state stress granule interactome and insights to neurodegeneration

The paper identifies over 100 novel stress granule proteins using proximity labeling and shows they form a dense interaction network, with implications for neurodegeneration.