Antigen affinity and site of immunization dictate B cell recall responses
M. Termote, R. C. Marques, E. Hyllner, M. V. Guryleva, M. Henskens, A. Brutscher, I. J. L. Baken, X. Castro Dopico, A. Dalmau Gasull, B. Murrell, L. Stamatatos, L. S. Westerberg, P. Dosenovic
This study shows that antigen affinity and immunization site influence B cell recall responses, with low affinity boosts leading to higher SHM but fewer memory B cells in secondary GCs.
bioRxiv · Apr 19, 2024Immunology