Nucleoside-modified mRNA-based influenza vaccines circumvent problems associated with H3N2 vaccine strain egg-adaptation
S. Gouma, K. Parkhouse, M. Weirick, H. Muramatsu, N. Pardi, S. H. Y. Fan, D. Weissman, S. E. Hensley
This study compares H3N2 vaccine efficacy between mRNA-LNP and egg-based vaccines, finding that mRNA-LNP vaccines elicit better neutralizing antibodies and protection against wild-type H3N2 virus.
bioRxiv · Jul 6, 2022Microbiology