Rapid and consistent evolution of colistin resistance in Pseudomonas aeruginosa during morbidostat culture
B. Regenbogen, M. Willmann, M. Steglich, B. Bunk, U. Nubel, S. Peter, R. A. Neher
This study shows that colistin resistance in Pseudomonas aeruginosa evolves rapidly and consistently in morbidostat cultures, with mutations targeting specific genes involved in lipopolysaccharide synthesis and signaling.
bioRxiv · Oct 14, 2016Microbiology