Expanding the DNA editing toolbox: novel lambda integrase variants targeting microalgal and human genome sequences.
S. J. Wei, A. A. Siddiqui, L. S. Yi, S. Kannan, S. Peter, Z. Yingying, C. Verma, P. Droge, J. F. Ghadessy
This paper describes the directed evolution of lambda integrase variants that target microalgal and human genome sequences, showing enhanced specificity for non-natural sites.
bioRxiv · Sep 22, 2023 · PreprintBioengineering