Genetic mechanisms of resistance to targeted KRAS inhibition
Bianca Jay Diaz, M.S. Kops, Sara Bernardo, Henri Schmidt, Elizabeth Grankowsky, Adrian Vega, Chen Zhang, Matthew Joseph Bott, Maria Skamagki, Aidan C.A. Tomlinson, Nicole A. Vita, Alyna Katti, Mark P. Labrecque, Ida Aronchik, Mallika Singh, Lukas E. Dow
This study identifies genetic mechanisms of resistance to KRAS inhibitors by using CRISPR screens to find resistance mutations and signaling rewiring in NSCLC.
bioRxiv · Aug 4, 2025 · PreprintCancer Biology