Author

Madeleine L. Ware

The University of Texas at Austin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Organism:mouse· 1

Frequent Co-Authors

5· 2 shared Adam H. Libby· 2 shared Ku‐Lung HsuiD· 2 shared Olivia L. MurtaghiD· 2 shared AeRyon KimiD· 1 shared Aizhen Xiao· 1 shared Benjamin W. PurowiD· 1 shared Bissan Al‐LazikaniiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

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Author profile →

3 papers

Recent·Most cited

A Chemoproteomic Atlas of the Human Purine Interactome for Regioselective Ligand Discovery

Zhihong Li, Hsiao-Kuei Tsai, Adam H. Libby, Michael W. Founds, Olivia L. Murtagh, Madeleine L. Ware, David M. Leace, 5, Phillip W. Gingrich, Bissan Al‐Lazikani, Chin‐Yuan Chang, Ku‐Lung Hsu

The paper develops a chemoproteomics platform to map the human purine interactome and identifies a regioselective ligand for ACAT2 with potential therapeutic applications in cancer.

Nature Communications · Jun 5, 2026Peer-reviewedBiochemistry

Re-Engineering P(V) Chemical Warfare: Harnessing Stereogenic Phosphorus-Azoles for Protein Ligand Discovery In Vivo

R. Justin Grams, Olivia L. Murtagh1, Madeleine L. Ware, Serhii Vasylevskyi, Ku‐Lung Hsu

The paper develops PhAzE chemistry to selectively target serine hydrolases in vivo with minimal toxicity, demonstrating the potential of stereogenic P(V) compounds for protein ligand discovery.

bioRxiv · Jan 28, 2026 · PreprintBiochemistry

Stereoselective Degradation of Diacylglycerol Kinases Potentiate T cell Activation and Tumor Cell Cytotoxicity

Minhaj Shaikh, Surya Pravo Mookherjee, Claire C. Weckerly, Adam H. Libby, Aizhen Xiao, Yunge Zhao, Sagar D. Vaidya, AeRyon Kim, Zhihong Li, Madeleine L. Ware, Michelle Marants, Olivia L. Murtagh, 5, Timothy N. J. Bullock, Benjamin W. Purow, , Ku-Lung Hsu

This study identifies a stereoselective DGK inhibitor that enhances T cell activation and tumor cell cytotoxicity through proteasome-dependent degradation of DGK.

bioRxiv · Dec 12, 2025 · PreprintBiochemistry