Author

Magdalena Bugno

Hospital for Sick Children

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:statistical model· 2 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Amit G. DeshwariD· 2 shared Brandon VaziD· 2 shared Erle M. Holgersen· 2 shared Jovanka J. Bogojeski· 2 shared Kahlin Cheung-Ong· 2 shared Ken J. KroniD· 2 shared Marta Verby· 2 shared Shreshth GandhiiD· 2 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBioinformatics

Amit G. DeshwarORCID

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Author profile →

2 papers

Recent·Most cited

An RNA foundation model enables discovery of disease mechanisms and candidate therapeutics

Albi Celaj, Alice Jiexin Gao, Tammy Lau, Erle M. Holgersen, Alston Lo, Varun Lodaya, Christopher B. Cole, Robert Edward Denroche, Carl Spickett, Omar Wagih, Pedro O. Pinheiro, Parth Vora, Pedrum Mohammadi‐Shemirani, Steve Chan, Zach Nussbaum, , Brendan J. Frey

The paper introduces BigRNA, an RNA foundation model that predicts RNA biology from DNA sequence and identifies therapeutic effects of SBOs on gene expression and splicing.

bioRxiv · Sep 20, 2023 · PreprintBioinformatics

Transcriptome-Wide Off-Target Effects of Steric-Blocking Oligonucleotides

Erle M. Holgersen, Shreshth Gandhi, Yongchao Zhou, Jinkuk Kim, Brandon Vaz, Jovanka J. Bogojeski, Magdalena Bugno, Zvi Shalev, Kahlin Cheung-Ong, João Gonçalves, Matthew O'hara, Ken J. Kron, Marta Verby, Mark Sun, Boyko Kakaradov, , Amit G. Deshwar

This study evaluates off-target effects of steric-blocking oligonucleotides using RNA-seq and finds that in silico methods have limited utility for predicting these effects.

Nucleic Acid Therapeutics · Aug 13, 2021Peer-reviewedMolecular Biology