Pan-cancer proteogenomic interrogation of the Ubiquitin Proteasome System
Tania J González-Robles, Maha Khan, Paul Sastourne-Haletou, Marisa Triola, Hua Zhou, Yuki Kito, Sharon Kaisari, David Fenyö, Gergely Róna, Yadira M. Soto‐Feliciano, Benjamin G. Neel, Kelly V. Ruggles, Michele Pagano
Proteogenomic analysis of up to 11 CPTAC cohorts shows ubiquitin-proteasome proteins often diverge from transcripts; TP53-mutant tumors elevate UBR5 protein, while TRIM28 prognosis is lineage-dependent.
Cell Death and Differentiation · Jul 19, 2026Peer-reviewedSystems Biology✦ In-depth digest