Gergely Róna

Proteogenomic analysis of up to 11 CPTAC cohorts shows ubiquitin-proteasome proteins often diverge from transcripts; TP53-mutant tumors elevate UBR5 protein, while TRIM28 prognosis is lineage-dependent.

The paper integrates multiple affinity purification strategies to uncover novel protein interactions, validating the FOXA1-PBX1 complex as a regulatory node in estrogen receptor transcription.

The paper identifies phosphoproteomic changes in Huntington's disease patient-derived neurons, revealing dysregulated post-translational modifications and potential compensatory mechanisms.

This study identifies GMCL1 as a negative regulator of the mitotic stopwatch pathway, showing it promotes 53BP1 degradation and reduces paclitaxel sensitivity in cancer cells.

This study identifies dUTPase as a mitotic regulator essential for early embryonic development, showing its role in centrosome integrity and spindle dynamics beyond its known nucleotide sanitization function.

This study reveals how two F-box proteins, FBXO22 and FBXL17, recognize distinct structural features of the BACH1 BTB dimer under oxidative stress, leading to its ubiquitination and degradation.

The paper shows cyclin D1-CDK4/6 stabilizes GTSE1, promoting cell proliferation and poor cancer prognosis.

This study shows D-type cyclins inhibit mismatch repair (MMR) in G1 phase by shielding p21, while their degradation in S phase enables proper MMR function, maintaining genome stability.

This study shows that dUTPase is essential for post-implantation development in mice, as dUTPase knock-out embryos die shortly after implantation.