Harnessing the adaptive potential of mechanoresponsive proteins to overwhelm pancreatic cancer dissemination and invasion
Alexandra Surcel, Eric Schiffhauer, Dustin Thomas, Qingfeng Zhu, Kathleen DiNapoli, Maik Herbig, Oliver Otto, Jochen Guck, Elizabeth Jaffee, Pablo Iglesias, Robert Anders, Douglas Robinson
This study identifies mechanoresponsive proteins upregulated in pancreatic cancer and shows that modulating their activity with 4-HAP reduces metastasis and invasion in vitro and in vivo.
bioRxiv · Sep 19, 2017 · PreprintCancer Biology