LRBA promotes drug-induced liver injury and MASLD by scaffolding MAPK activation
Daisuke Oikawa, Min Gi, Yoshinori Okina, Duc Pham Minh, Hidetaka Kosako, Lê Thị Thanh Thủy, Yusuke Sato, Hiroko Ikenaga, Mana Kosugi, Tsutomu Matsubara, Kouhei Shimizu, Masayuki Shiota, Fumiaki Ando, Shinichi Uchida, Hirotaka Takahashi, , Fuminori Tokunaga
This study identifies LRBA as a scaffold promoting MAPK activation, leading to drug-induced liver injury and MASLD by enhancing inflammatory signaling.
bioRxiv · Nov 17, 2025 · PreprintCell Biology