Cigarette Smoke Activates NOTCH3 to Promote Goblet Cell Differentiation in Human Airway Epithelial Cells
Manish Bodas, Andrew R. Moore, Bharathiraja Subramaniyan, Constantin Georgescu, Jonathan D. Wren, Willard M. Freeman, Brent R. Brown, Jordan P. Metcalf, Matthew S. Walters
This study shows that cigarette smoke activates NOTCH3, promoting goblet cell differentiation in human airway epithelial cells, contributing to COPD-related goblet cell metaplasia.
bioRxiv · Jul 9, 2020Cell Biology