Author

Manolis Kellis

Primary ORCID profile (0000-0001-7113-9630 · 6 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Manolis KellisiD6 papers · Broad Institute

Biology Disciplines

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Genomics· 4 Genetics· 2

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:statistical model· 5 Assay:ChIP-seq· 3 Research Focus:differential expression· 3 Assay:DNA methylation· 3 Research Focus:gene regulatory network inference· 3 Assay:bulk RNA-seq· 2 Research Focus:eQTL / molecular QTL mapping· 2

Frequent Co-Authors

Andrew A. Brown· 2 shared Ayellet V. Segrè· 2 shared Benjamin J. Strober· 2 shared Christine B. Peterson· 2 shared Eleazar Eskin· 2 shared Emmanouil T. Dermitzakis· 2 shared Eric R. Gamazon· 2 shared François Aguet· 2 shared

Activity by Year

2014-2016 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenomics

Andrew A. Brown

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6 papers

Recent·Most cited

Distant regulatory effects of genetic variation in multiple human tissues

Brian Jo, Yuan He, Benjamin J. Strober, Princy Parsana, François Aguet, Andrew A. Brown, Stephane E. Castel, Eric R. Gamazon, Ariel Gewirtz, Genna Gliner, Buhm Han, Amy Z. He, Eun Yong Kang, Ian C. McDowell, Xiao Li, , Alexis Battle

The paper identifies trans-eQTLs in multiple human tissues and shows their tissue-specific effects and association with disease.

bioRxiv · Sep 9, 2016 · PreprintGenomics

Local genetic effects on gene expression across 44 human tissues

François Aguet, Andrew A. Brown, Stephane E. Castel, Joe R. Davis, Pejman Mohammadi, Ayellet V. Segrè, Zachary Zappala, Nathan S. Abell, Laure Frésard, Eric R. Gamazon, Ellen Gelfand, Michael J. Gloudemans, Yuan He, Farhad Hormozdiari, Xiao Li, , Stephen B. Montgomery

This study identifies cis-eQTLs across 44 human tissues using GTEx data, showing 88% of genes have cis-eQTLs and demonstrating their utility in understanding complex trait etiology.

bioRxiv · Sep 9, 2016 · PreprintGenomics

Evidence of a recombination rate valley in human regulatory domains

Yaping Liu, Abhishek Sarkar, Manolis Kellis

The paper identifies recombination rate valleys in human regulatory domains, showing reduced recombination and increased evolutionary constraint in gene-regulatory regions.

bioRxiv · Apr 15, 2016 · PreprintGenomics

Functional enrichments of disease variants across thousands of independent loci in eight diseases

Abhishek K. Sarkar, Lucas D. Ward, Manolis Kellis

The paper identifies weak regulatory associations in eight diseases, showing they are enriched in disease-relevant regions and pathways, and develops methods to analyze these associations.

bioRxiv · Apr 11, 2016 · PreprintGenetics

Various localized epigenetic marks predict expression across 54 samples and reveal underlying chromatin state enrichments

Lalita Devadas, Angela Yen, Manolis Kellis

The paper predicts gene expression from epigenetic features across 54 samples using machine learning, showing high accuracy in cell cultures and varying importance of histone marks.

bioRxiv · Nov 3, 2015 · PreprintGenetics

Phylogenetic Identification and Functional Characterization of Orthologs and Paralogs across Human, Mouse, Fly, and Worm

Yi-Chieh Wu, Mukul S. Bansal, Matthew D. Rasmussen, Javier Herrero, Manolis Kellis

The paper identifies and characterizes orthologs and paralogs across human, mouse, fly, and worm using phylogenomic methods and functional genomic data.

bioRxiv · May 31, 2014 · PreprintGenomics