IKAROS Gene Regulatory Network Reveal ERG as a Vulnerability in B-cell Acute Lymphoblastic Leukemia
Hana Paculová, Alyssa R. Richman, Joseph Boyd, Joshua Carlos Bernil, Princess Rodriguez, Etapong Fonabei Ayongaba, Prachi N. Ghule, Elsa Drivet, Amrita Palaria, Mariam Dajani, Els Verhoeyen, Anthony J. Saviola, Gary S. Stein, Hilde Schjerven, Seth E. Frietze
This study identifies ERG as a vulnerability in IKZF1-mutated B-cell acute lymphoblastic leukemia through gene regulatory network analysis and functional validation.
bioRxiv · Dec 29, 2025 · PreprintCancer Biology