APOE4 increases energy metabolism in APOE-isogenic iPSC-derived neurons
Vanessa Budny, Yannic Knöpfli, Deborah Meier, Kathrin Zürcher, Chantal Bodenmann, Siri L. Peter, Terry Müller, Marie Tardy, Cédric Cortijo, Christian Tackenberg
This study shows APOE4 increases mitochondrial ATP production in neurons compared to other APOE isoforms, suggesting a gain-of-function effect on neuronal energy metabolism.
bioRxiv · Jun 3, 2024Neuroscience