Genetic variation at 11q23.1 confers colorectal cancer risk by dysregulation of colonic tuft cell transcriptional activator POU2AF2
Vidya Rajasekaran, Bradley T. Harris, Ruby Tamara Osborn, Claire L. Smillie, Kevin Donnelly, Marion Bacou, Edward Esiri-Bloom, Li Yin Ooi, Morven Allan, Marion Walker, Stuart Reid, Alison M. Meynert, Graeme R. Grimes, James Peter Blackmur, Peter G Vaughan-Shaw, , Susan Mary Farrington
This study identifies rs3087967 as the causal variant at 11q23.1 that increases colorectal cancer risk by dysregulating POU2AF2, a key activator of tuft cell transcription.
Gut · Nov 28, 2024Peer-reviewedGenetics