Author

Marisa Actis

St. Jude Children's Research Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Approach:experimental assay· 1

Frequent Co-Authors

Anand Mayasundari· 2 shared Anup AggarwaliD· 2 shared Gisele NishiguchiiD· 2 shared Lei YangiD· 2 shared Zoran RankovićiD· 2 shared Anastasia Bednarz· 1 shared Angelina Li· 1 shared Bachuki ShashikadzeiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersBiochemistry

Anand Mayasundari

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Unbiased mapping of cereblon neosubstrate landscape by high-throughput proteomics

Martin Steger, Gisele Nishiguchi, Qiong Wu, Bjoern Schwalb, Bachuki Shashikadze, Kevin M. McGowan, Marisa Actis, Anup Aggarwal, Zhe Shi, Jeanine E. Price, Anand Mayasundari, Lei Yang, Anastasia Bednarz, Sophie Machata, Tobias Graef, , Zoran Ranković

Proteomics and ubiquitinomics screening of 100 CRBN ligands in two cell lines validated 50 novel neosubstrates and yielded selective phenyl glutarimide degraders of KDM4B, G3BP2 and VCL.

Nature Communications · Aug 20, 2025Peer-reviewedBiochemistry✦ In-depth digest

LCK-targeting molecular glues overcome resistance to inhibitor-based therapy in T-cell acute lymphoblastic leukemia

Jun J Yang, Gisele Nishiguchi, Satoshi Yoshimura, Marisa Actis, Justin T. Seffernick, Jamie Jarusiewicz, Anup Aggarwal, Angelina Li, Yong Li, Dong Geun Lee, Lei Yang, Anand Mayasundari, Zoran Ranković, Marcus M. Fischer

This study develops LCK-targeting molecular glues that overcome resistance to kinase inhibitors in T-ALL by inducing CRBN-dependent degradation of LCK.

bioRxiv · Jul 3, 2025 · PreprintCancer Biology