Cancer BiologybioRxivPreprint
LCK-targeting molecular glues overcome resistance to inhibitor-based therapy in T-cell acute lymphoblastic leukemia
Jun J Yang, Gisele Nishiguchi, Satoshi Yoshimura…·Marcus M. Fischer
This study develops LCK-targeting molecular glues that overcome resistance to kinase inhibitors in T-ALL by inducing CRBN-dependent degradation of LCK.
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